Naltrexone, in its full dose form, is in the opioid antagonists drug class. It blocks opiate drivs from binding to the opioid receptors, which results in endorphin increase and release of enkephalin. This causes three areas to be reduced: 1) signal and release of inflammatory substances, 2) nerve cell inflammation, and 3) autoimmune mediators. Low Dose Naltrexone (LDN) is an affordable medication with many success stories in Integrative and Functional Medicine.
When taken at bedtime, the short-acting LDN binds to the receptors which leads to a brief blockade of opioid receptors. This blockade is believed to up-regulate vital elements of the immune system by causing an increase in endorphin and enkephalin production.